54. Towards better characterisation of molecular alterations in glioneuronal tumours
نویسندگان
چکیده
منابع مشابه
Molecular characterisation of soft tissue tumours: a gene expression study.
BACKGROUND Soft-tissue tumours are derived from mesenchymal cells such as fibroblasts, muscle cells, or adipocytes, but for many such tumours the histogenesis is controversial. We aimed to start molecular characterisation of these rare neoplasms and to do a genome-wide search for new diagnostic markers. METHODS We analysed gene-expression patterns of 41 soft-tissue tumours with spotted cDNA m...
متن کاملMolecular neuropathology of epilepsy-associated glioneuronal malformations.
Glioneuronal malformations (malformations of cortical development [MCD]) include focal cortical dysplasias (FCD) as well as highly differentiated glioneuronal tumors (i.e. gangliogliomas) and constitute frequent findings in patients with pharmacoresistent focal epilepsies. Tailored resection strategies evolved as promising treatment options and allow a systematic neuropathologic and molecular b...
متن کاملCerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma
Cell-free circulating tumour DNA (ctDNA) in plasma has been shown to be informative of the genomic alterations present in tumours and has been used to monitor tumour progression and response to treatments. However, patients with brain tumours do not present with or present with low amounts of ctDNA in plasma precluding the genomic characterization of brain cancer through plasma ctDNA. Here we s...
متن کاملmolecular and physiological characterizations of floral scent production in rosa damascena mill.
گل محمدی (r. damascena mill.)مهمترین گونه ای است که در تولید گلاب، عطر و اسانس، در صنعت عطرسازی و دارویی کاربرد دارد. با وجود اهمیت عطر گل محمدی، پژوهش های مولکولی و بیوشیمیایی عطر گل این گونه هنوز در مراحل ابتدایی است. در این پژوهش، ویژگی های مولکولی و فیزیولوژیکی تولید عطر در گل محمدی در آزمایش های مختلف مورد بررسی قرار گرفتند. در آزمایش اول، پژوهشی به منظور بررسی تنوع شیمیایی اسانس میان 44 ت...
Molecular-genetic characterisation of gliomas that recur as same grade or higher grade tumours.
BACKGROUND Due to their invasive growth, gliomas usually cannot be removed completely and almost always recur as same grade or higher grade malignancies. OBJECTIVE To determine whether there were differences in the accumulation of genetic changes between the two types of glioma recurrence. METHODS We genetically characterised 14 cases of lower grade glioma with a same grade recurrence, 12 c...
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ژورنال
عنوان ژورنال: Pathology
سال: 2020
ISSN: 0031-3025
DOI: 10.1016/j.pathol.2020.01.054